Table 1.

Priorities for future directions in astrocytic tau propagation in the context of AD.

Known	Unknown
Astrocytes have very low endogenous levels of tau but can internalize tau from the extracellular matrix and ghost tangles.	What is the mechanism for monomeric tau internalization in astrocytes?
Astrocytes play a key role in neuronal health and astrocytic tau internalization alters astrocyte morphology and function.	At what rate do astrocytes degrade/propagate tau?
While microglia also play a role in tau internalization, astrocytic changes are understudied in the context of tau pathology in AD.	What are the repercussions to neurons when astrocytes internalize tau?