Fig. 3.

ACE2 localization in kidney and heart tissue of the db/m, db/db and db/db treated with ramipril mice. ACE2 was immunodetected in kidney and heart sections. In the kidney, ACE2 is located at the brush border of the tubular cells with a more prominent staining in db/db than in db/m. Ramipril did not induce major localization changes. ACE2 in heart showed a diffuse distribution with increased ACE2 staining in some areas. The staining intensity seemed to decrease in the db/db when compared to the db/m.