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. 2021 Mar 18;7(3):e06386. doi: 10.1016/j.heliyon.2021.e06386

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© 2021 Published by Elsevier Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Forest plots for analysis of per-vessel detection of >50% stenosis. Heterogeneity is reported as I² and Cochran's Q statistic, for which a p-value is reported. 95% Confidence intervals were calculated using the Clopper-Pearson method for each study and the pooled statistics. A. Per-vessel sensitivity = 0.837 (0.797–0.878); I² = 0%, p = 0.77. B. Per-vessel specificity = 0.900 (0.867–0.934); I² = 63%, p = 0.03. C. Per-vessel PPV = 0.761 (0.687–0.835); I² = 63%, p = 0.03. D. Per-vessel NPV = 0.939 (0.920–0.958); I² = 21%, p = 0.28. Sensitivity and NPV show weak heterogeneity while specificity and PPV have significant heterogeneity.