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. 2021 Mar 18;7(3):e06386. doi: 10.1016/j.heliyon.2021.e06386

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© 2021 Published by Elsevier Ltd.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Forest plots for analysis of per-segment detection of >50%. Heterogeneity is reported as I² and Cochran's Q statistic, for which a p-value is reported. 95% Confidence intervals were calculated using the Clopper-Pearson method for each study and the pooled statistics. A. Per-segment sensitivity = 0.816 (0.768–0.864); I² = 0%, p = 0.93. B. Per-segment specificity = 0.970 (0.955–0.985); I² = 79%, p < 0.01. C. Per-segment PPV = 0.744 (0.669–0.818); I² = 53%, p = 0.10. D. Per-segment NPV = 0.981 (0.972–0.991); I² = 59%, p = 0.06. Specificity shows weak heterogeneity while sensitivity, PPV, and NPV have significant heterogeneity.