Table 1.
Comparison of Clinicopathological Data Between dMMR and pMMR Colorectal Cancer
| pMMR n=183 | dMMR n=61 | Total n=244 | P value | |||
|---|---|---|---|---|---|---|
| Age | ||||||
| >55 | 154 | (84.2%) | 41 | (67.2%) | 195 | 0.004* |
| ≤55 | 29 | (15.8%) | 20 | (32.8%) | 49 | |
| Sex | ||||||
| Male | 113 | (61.7%) | 28 | (45.9%) | 141 | 0.030* |
| Female | 70 | (38.3%) | 33 | (54.1%) | 103 | |
| Location | ||||||
| Left | 47 | (25.7%) | 11 | (18.0%) | 58 | 0.000* |
| Right | 34 | (18.6%) | 39 | (63.9%) | 73 | |
| Rectum | 102 | (55.7%) | 11 | (18.0%) | 113 | |
| Diameter | ||||||
| ≦5 cm | 131 | (71.6%) | 27 | (44.3%) | 158 | 0.000* |
| >5 cm | 52 | (28.4%) | 34 | (55.7%) | 86 | |
| Lymphovascular invasion | ||||||
| Absent | 109 | (59.6%) | 42 | (68.9%) | 151 | 0.196 |
| Present | 74 | (40.4%) | 19 | (31.1%) | 93 | |
| Extranodal extension | ||||||
| Absent | 160 | (87.4%) | 57 | (93.4%) | 217 | 0.195 |
| Present | 23 | (12.6%) | 4 | (6.6%) | 27 | |
| T stage | ||||||
| T1-3 | 143 | (78.1%) | 23 | (37.7%) | 166 | 0.000* |
| T4 | 40 | (21.9%) | 38 | (62.3%) | 78 | |
| N stage | ||||||
| N0 | 116 | (63.4%) | 44 | (72.1%) | 160 | 0.298 |
| N1 | 47 | (25.7%) | 14 | (23.0%) | 61 | |
| N2 | 20 | (10.9%) | 3 | (4.9%) | 23 | |
| TNM stage | ||||||
| I | 23 | (12.6%) | 9 | (14.8%) | 32 | 0.501 |
| II | 94 | (51.4%) | 35 | (57.4%) | 129 | |
| III | 66 | (36.1%) | 17 | (27.9%) | 83 | |
| Tumor grade | ||||||
| I | 12 | (6.6%) | 5 | (8.2%) | 17 | 0.000* |
| II | 151 | (82.5%) | 31 | (50.8%) | 182 | |
| III | 20 | (10.9%) | 25 | (41.0%) | 45 | |
| Tumor type | ||||||
| NOS | 168 | (91.8%) | 47 | (77.0%) | 215 | 0.003*, a |
| Medullary | 0 | (0.0%) | 2 | (3.3%) | 2 | |
| Undifferentiated | 1 | (0.5%) | 0 | (0.0%) | 1 | |
| Signet ring | 1 | (0.5%) | 0 | (0.0%) | 1 | |
| Mucinous | 13 | (7.1%) | 12 | (19.7%) | 25 | |
Note: aFisher’s exact test,*P<0.05.