Table II.
Univariate and multivariate Cox proportional hazard models for overall survival.
| A, Univariate analysis | |||
|---|---|---|---|
| Variables | Hazard ratio | 95% CI | P-value |
| RDW | 2.95 | 1.70-5.12 | <0.001 |
| Age | 1.74 | 1.16-2.60 | 0.007 |
| Sex | 0.61 | 0.40-0.95 | 0.027 |
| Body mass index | 1.05 | 0.71-1.55 | 0.809 |
| Brinkman index | 1.37 | 0.91-2.04 | 0.128 |
| Anemia | 1.09 | 0.58-2.04 | 0.787 |
| Carcinoembryonic antigen | 1.91 | 1.28-2.84 | 0.001 |
| Diabetes mellitus | 0.87 | 0.49-1.53 | 0.628 |
| Heart disease | 1.89 | 1.01-3.55 | 0.047 |
| History of malignancy | 1.66 | 1.04-2.65 | 0.034 |
| Charlson Comorbidity Index | 2.17 | 1.40-3.37 | <0.001 |
| %VC | 2.78 | 1.13-6.87 | 0.027 |
| FEV1.0% | 1.47 | 0.96-2.24 | 0.078 |
| SUVmax | 2.50 | 1.52-4.13 | <0.001 |
| cTNM | |||
| I | 1 | ||
| II | 2.22 | 1.35-3.63 | 0.002 |
| III | 5.50 | 2.00-15.11 | 0.001 |
| Pathological subtype | |||
| Adenocarcinoma | 1 | 0.56-1.90 | 0.918 |
| Squamous cell carcinoma | 1.03 | 1.10-3.35 | 0.022 |
| Others | 1.92 | ||
| B, Multivariate analysis | |||
| Variables | Hazard ratio | 95% CI | P-value |
| RDW | 2.29 | 1.3-4.01 | 0.004 |
| Carcinoembryonic antigen | 1.89 | 1.26-2.84 | 0.002 |
| Charlson Comorbidity Index | 2.28 | 1.26-2.84 | <0.001 |
| SUVmax | 1.98 | 1.19-3.3 | 0.009 |
| cTNM | |||
| I | 1 | ||
| II | 1.70 | 1.03-2.81 | 0.039 |
| III | 7.05 | 2.51-19.8 | <0.001 |
Multivariate analysis was conducted with the stepwise backward elimination method with a probability level of 0.15. Covariates with P<0.05 in the univariate analysis were entered into the Cox model. RDW, red blood cell distribution width; VC, vital capacity; FEV1.0, forced expiratory volume in 1 sec; SUVmax, maximum standardized uptake value; cTNM, clinical TNM stage.