Table 5.
Candidate drug targeting genes with PAH.
| Gene | Drug | Sources | Reference (PMID) |
|---|---|---|---|
| SPP1 | Alteplase | NCI | 12009309 |
| SPP1 | Gentamicin | NCI | 11274264 |
| SPP1 | Tacrolimus | NCI | 16103732 |
| SPP1 | Calcitonin | NCI | 8013390 |
| VCAM1 | Cyclosporine | NCI | 7694584 |
| VCAM1 | Carvedilol | DrugBank | 17139284, 15374848, 17016423 |
| VCAM1 | Alcohol | DrugBank | 18165316 |
| VCAM1 | Mercaptopurine | NCI | 7694584 |
| VCAM1 | Dexamethasone | NCI | 7694584 |
| CXCL12 | Vincristine | PharmGKB | 27173875 |
| CXCL12 | Alemtuzumab | PharmGKB | 27173875 |
| CXCL12 | Prednisone | PharmGKB | 27173875 |
| CXCL12 | Cyclophosphamide | PharmGKB | 27173875 |
| CXCL12 | Chlorambucil | PharmGKB | 27173875 |
| CXCL12 | Rituximab | PharmGKB | 27173875 |
| CXCR1 | Ibuprofen | TTD | N/A |
| CXCR1 | Ketoprofen | DrugBank | 9093816, 15974585, 11331079 |
Note: PAH: pulmonary arterial hypertension; NCI: National Cancer Institute; TTD: Therapeutic Target Database; N/A: not available.