Table 1.
Spheroid and Scaffold models for radiation response studies
| Platform | Author | Date | Cancer Type/ Cell Line | Key Findings |
|---|---|---|---|---|
| Spheroid Model | Hehlgans et al57 | 2009 | Pancreatic Cancer: MiaPacCa2 | Identified increased sensitivity to radiation with membrane protein (Caveolin-1) knock down in MiaPacCa2. |
| Spheroid Model | Hehlgans et al84 | 2009 | Pancreatic Cancer: MiaPaCa-1 PANC-1 Head and Neck: HNSCC Lung Cancer Cells: A549 Colorectal Cancer: DLD-1, HCT-116 |
Radio-sensitivity of pancreatic cancer cell lines human head and neck, lung, and colorectal cell lines by the focal adhesion kinase inhibitor (TAE226) |
| Spheroid Model | Longati et al82 | 2013 | Pancreatic cancer PDAC | Identified chemo-radio resistance in PDAC spheroids when compared to 2D cell-culture systems |
| Co-culture Spheres & Xenografts |
Al-Assar et al66 | 2014 | Pancreatic Cancer: PANC-1 |
Co-culture of stellate cells (PSC) and PANC-1 were more radio-resistant in spheres and mouse models. |
| Spheroid Model | Al-Ramadan et al83 | 2018 | Pancreatic Cancer: BON-1 | 7-day post-radiation treatment revealed dose-dependent increase in apoptosis in BON-1 |
| Polyurethane Scaffold | Gupta et al12 | 2019 | Pancreatic Cancer: PANC-1 | PU scaffolds can be utilised as a radiation response platform. Variations in post-treatment response after short-term (24 h) and long-term (17 days) PANC-1 culture. |