. 2021 Feb 7;6(3):100666. doi: 10.1016/j.adro.2021.100666

Table 1.

Multivariable logistic regression modeling for association between dose-function metrics and radiation-induced lung toxicity

Modality	Timepoint	n	Structure	Metric	Odds ratio	95% Confidence interval	P-value
Perfusion	Before treatment	88	Lungs-GTV	Volume, cc	1.02–	0.50–2.01	.95
				V₂₀, %	1.05–	0.94–1.17	.39
				ADL, Gy	1.12–	1.02–1.25	.02
				iV₂₀, a.u.	0.08–	0.01–0.91	.05
			Ipsilateral lung-GTV	Volume, cc	0.85–	0.16–4.05	.84
				V₂₀, %	1.01–	0.96–1.07	.66
				ADL, Gy	1.05–	1.00–1.10	.07
				iV₂₀, a.u.	0.05–	0.00–0.69	.03
			Contralateral lung-GTV	Volume, cc	0.91–	0.25–2.97	.87
				V₂₀, %	1.00–	0.86–1.15	.95
				ADL, Gy	1.52–	1.06–2.23	.03
				iV₂₀, a.u.	0.82–	0.13–4.88	.83
Ventilation	Before treatment	88	Lungs-GTV	Volume, cc	1.00–	0.49–1.98	.99
				V₂₀, %	1.06–	0.95–1.19	.29
				ADL, Gy	1.14–	1.03–1.26	.01
				iV₂₀, a.u.	0.06–	0.00–0.64	.02
			Ipsilateral lung-GTV	Volume, cc	0.87–	0.17–3.99	.86
				V₂₀, %	1.02–	0.97–1.08	.39
				ADL, Gy	1.05–	1.00–1.10	.08
				iV₂₀, a.u.	0.06–	0.00–0.61	.03
			Contralateral lung-GTV	Volume, cc	1.47–	0.41–5.10	.54
				V₂₀, %	0.99–	0.85–1.12	.88
				ADL, Gy	1.36–	0.92–2.01	.12
				iV₂₀, a.u.	1.24–	0.15–9.27	.83

Abbreviations: ADL = average dose to the lower region of lung structure in Gy; GTV = gross tumor volume; iV₂₀ = average normalized functional intensity receiving ≥20 Gy in arbitrary units; V₂₀ = volume of lung structure receiving ≥20 Gy as a percent of total lung structure volume; volume = normal lung volume excluding GTV.