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. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: Neuropharmacology. 2021 Jan 16;186:108463. doi: 10.1016/j.neuropharm.2021.108463

Fig. 1. Serum 3α,5α-THP levels are higher in female vs male rats following vehicle and 3α,5α-THP administration.

Fig. 1.

As expected, female rats showed higher levels of circulating 3α,5α-THP (males = 5.703 ± 1.02 ng/ml vs females = 37.59 ± 4.2 ng/ml, p = 0.0006). Following 3α,5α-THP (15 mg/kg) IP administration, plasma 3α,5α-THP levels were increased in both male and female rats (males VEH = 5.703 ± 1.02 ng/ml vs 3α,5α-THP = 97.46 ± 5.8 ng/ml, p < 0.0001; females VEH = 37.59 ± 4.2 ng/ml vs 3α,5α-THP = 181 ± 7 ng/ml, p < 0.0001); this increase was significantly different between male and female rats (males = 91.76 ± 5.8 ng/ml vs females = 143.41 ± 7 ng/ml; t (8) = 14.77, p < 0.001) (n = 4–7 per group). Significant effect was found using Two-way ANOVA, followed by Tukey HSD test, ****p < 0.0001. Data are represented as mean ± SEM. VEH = rats treated with vehicle; 3α,5α-THP = rats treated with 3α,5α-THP.