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. 2021 Mar 16;9:628415. doi: 10.3389/fcell.2021.628415

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Copyright © 2021 Kumar and Mohapatra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Base modifications in mRNA affect post-transcriptional gene regulation. In the nucleus, RNA base modifications affect (1) pre-mRNA processing and (2) pri-miRNA maturation, and (3) their export from the nucleus. In the cytoplasm, RNA base modifications regulate (4) mRNA degradation, (5) mRNA stability, (6) RNA structure, and (7) mRNA translation efficiency.

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