FIGURE 3.

(A) Pharmacodynamic calcineurin (CN) activity-time profiles along 12 h dose interval after the administration of morning and night dose of twice-daily Tac. (B) Estimation of the total daily CN inhibition using I _min as baseline (AUE_0–24 h I_min) (red square) by doubling the inhibition after the morning Tac dose (AUE_0–12 I_min x2) (red round) and (C), estimating the inhibition using I_nadir as baseline, AUE_0–24 h I_nadir (red square) and AUE_0–12 h I_nadir x2 (red round). Each point joined by a line represented one patient. Paired t-test between both estimations was applied. (D,E) Correlations between all whole blood Tac concentrations and CN activities sampling after morning and night dose, respectively. Pearson test of Ln transformed data were performed for correlation analysis.