Table 1.
Biological function categories altered by chronic ethanol feeding
| Control Versus Ethanol | ||||||
|---|---|---|---|---|---|---|
| Categories | Diseases or Functions Annotation | P-Value | Predicted Activation State | Activation Z-Score | Molecules | # Molecules |
| Lipid metabolism | Concentration of lipids | 5.82E-09 | Increased | 2.273 | Abcb11,Abcc2,Abcc3,Abhd6,Apoc4,Asgr2,Atp7b,Ccny,Ceacam1,Cideb,Clu,Cr1l,Cyp17a1,Cyp2e1,Dhcr7,Dio1,Egfr,Epb41,Fdft1,Fmo5,Gna11,Gnaq,Hsd17b4,Itgb3,Lima1,Mgll,Pctp,Pitpna,Plin3,Plin5,Pnpla2,Prkcd,Ptpmt1,Rab7a,Rgn,Sc5d,Slc22a1,Slc9a3r1,Slco1a1,Steap4,Uqcrfs1,Vac14,Xdh | 43 |
| Molecular transport | Transport of carboxylic acid | 9.49E-09 | Decreased | −2.091 | Abcb11,Abcc2,Abcc3,Atp7b,Bsg,Cpt2,Prkcd,Slc16a4,Slc23a1,Slc25a1,SlSlc26a1,Slco1a1,Slco1a4 | 13 |
| Molecular transport | Transport of ion | 6.23E-06 | Decreased | −2.204 | Abcc2,Abcc3,Ano10,Atp2b1,Atp6v0a1,Atp7b,Ca3,Coro1a,Gjb1,Nnt,Nsf,Rab11b,Slc17a2,Slc22a1,Slc23a1,Slc26a1,Slc9a3r1,Slco1a1,Slco1a4,Steap4,Stim1,Vdac2 | 22 |
IPA, ingenuity pathway analysis; LD, lipid droplet.
The status of enriched biological function categories of LD-associated proteins altered by ethanol feeding based on Z-scores assigned by the IPA.