Table 2.
Biological function categories modulated by fasting of ethanol-fed (ethanol-fast) rats
| Control Versus Ethanol Fasted | ||||||
|---|---|---|---|---|---|---|
| Categories | Diseases or Functions Annotation | P-value | Predicted Activation State | Activation Z-Score | Molecules | # Molecules |
| Lipid metabolism | Hydroxylation of lipid | 5.5E-11 | Increased | 2.127 | Cyb5a,Cyp27a1,Cyp2e1,Cyp4b1, | 4 |
| Lipid metabolism | Concentration of fatty acids | 7.88E-08 | Increased | 2 | Abcd1,Abcg2,Casp1,Cyp27a1,Cyp2e1,Decr1,Egfr,Faah,Fads2,G0s2,Gna11, sd17b4,Pck1,Pcp,Pnpla2,Ptgs1,Scarb1,Slc2a2 | 18 |
| Lipid metabolism | Conjugation of eicosanoid | 3.83E-07 | Increased | 2.219 | Faah,Ugt1a1,Ugt2b10 | 3 |
| Lipid metabolism | Conjugation of 12-hydroxyeicosatetraenoic acid | 6.21E-06 | Increased | 2 | Ugt1a1,Ugt2b10 | 2 |
| Cellular function | Exocytosis by cells | 1.75E-05 | Increased | 2.442 | Arf6,Napa,Rab21,Rab5a,Rab9a,Rhoa | 6 |
| Cellular function | Secretory pathway | 6.77E-05 | Increased | 2.428 | Arf6,Napa,Prkcd,Rab11b,Rab21,Rab5a,Rab9a,Rhoa,Sptbn2 | 9 |
| Cellular function | Exocytosis | 0.000125 | Increased | 2.428 | Arf6,Napa,Prkcd,Rab21,Rab5a,Rab9a,Rhoa,Sptbn2 | 8 |
| Molecular transport | Transport of carboxylic acid | 1.96E-12 | Decreased | −2.09 | Abcb11,Abcc2,Abcc3,Abcc6,Abcd1,Abcd3,Abcg2,Alb,Ca14,Cpt2,Prkcd,Scarb1,Slc16a2,Slc23a1,Slc26a1,Slc27a2,Slc2a2, Slco1a1,Slco1a4 | 19 |
| Lipid metabolism | Transport of fatty acid | 1.16E-09 | Decreased | −2.182 | Abcc2,Abcc3,Abcc6,Abcd1,Abcd3,Abcg2,Alb,Cpt2,Prkcd,Scarb1,Slc27a2,Slco1a1,Slco1a4 | 13 |
IPA, ingenuity pathway analysis; LD, lipid droplet.
Status of enriched biological function categories of LD-associated proteins modulated by fasting of ethanol-fed rats, based on Z-scores assigned by the IPA.