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SEC elution profiles of FN3Con-anti-VEGFR2 after accelerated stability trials with a range of buffer excipients. All amino acid buffers slowed the loss of monomer. However, dimers appear at a similar rate between all samples, which could be linked to the generation of disulfide-bonded dimers due to degradation of BME. Tween80 was not significantly more destabilizing to the monomer than PBS buffer alone.
