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. 2021 Feb 19;296:100437. doi: 10.1016/j.jbc.2021.100437

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Mitochondrial defects in the zebrafish retina.A and B, assessment of mitochondrial function in the retina by enzyme histochemistry (EHC) staining for COX (A) and SDH (B) in the frozen sections of retina in the yars2^+/+, yars2^+/−, and yars2^−/− larvae at 5 dpf. Scale bar, 100 μm. C and D, mitochondrial morphology from photoreceptors (PR) (C) and RGC (D) of transmission electron microscopy. Ultrathin sections were visualized with 25,000× magnification. Scale bar, 1 μm. e, ellipsoid; m, mitochondrion; n, nucleus; os, outer segment of photoreceptors. E and F, quantification of mitochondrial numbers of photoreceptors (E) from yars2^+/+ (n = 20), yars2^+/− (n = 20), and yars2^−/− (n = 25) and RGC (F) from yars2^+/+ (n = 32), yars2^+/− (n = 24), and yars2^−/− (n = 25) zebrafish at 5dpf. Graph details and symbols are explained in the legend to Figure 2.