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[Preprint]. 2021 Mar 27:2021.03.26.437274. [Version 1] doi: 10.1101/2021.03.26.437274

Fig. 3. SARS-CoV-2 SApNP vaccines interact with follicular dendritic cells (FDCs) and are presented on FDC dendrites to B cells.

Fig. 3.

(A, B) S2GΔHR2 spike and S2GΔHR2-presenting E2p and I3–01 SApNP vaccine interaction with FDC networks in lymph node follicles 12 h after (A) a single-dose or (B) prime-boost injections (10 μg/injection, 40 μg/mouse). Vaccine antigens (the S2GΔHR2 spike and S2GΔHR2-presenting E2p and I3–01 SApNPs) colocalized with FDC networks. Immunostaining is color-coded (Green: CD21; Red: CD169; White: anti-spike). (C) Representative TEM images of an FDC surrounded by multiple B cells. S2GΔHR2-presenting I3–01 SApNPs (yellow arrows) presented on FDC dendrites.