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[Preprint]. 2021 Sep 9:2021.03.26.437274. Originally published 2021 Mar 27. [Version 4] doi: 10.1101/2021.03.26.437274

Fig. 5. SARS-CoV-2 SApNP vaccines interact with follicular dendritic cells (FDCs) and are presented on FDC dendrites to B cells.

Fig. 5.

(A, B) S2GΔHR2 spike and S2GΔHR2-presenting E2p and I3–01 SApNP vaccine interaction with FDC networks in lymph node follicles 12 h after (A) a single-dose or (B) prime-boost injections (10 μg/footpad, 40 μg/mouse). Vaccine antigens (the S2GΔHR2 spike and S2GΔHR2-presenting E2p and I3–01 SApNPs) colocalized with FDC networks. Immunostaining is color-coded (Green: CD21; Red: CD169; White: anti-spike), with scale bars of 500 μm and 100 μm shown for a complete lymph node and an enlarged image of a follicle, respectively. (C) Representative TEM images of an FDC surrounded by multiple B cells. S2GΔHR2-presenting I3–01 SApNPs (yellow arrows) presented on FDC dendrites.