Table 1. Top 5 pathways suggested by Gene Set Enrichment Analysis (GSEA).
28 WBM-regulated cytokines (including 17 common regulated factors between WBM and LT) were analyzed by GSEA and WIKI Pathways Gene Sets were selected. Top 5 pathways were presented with False Discovery Rate/FDR q values (< 0.05), p values (< 0.05) and k/K Value [Genes in Overlap (k) to Genes in Gene Set (K)].
| Gene Set Name (WIKI Pathways) | LUNG FIBROSIS | COVID19 ADVERSE OUTCOME PATHWAY | IL18 SIGNALING PATHWAY | CYTOKINES&INFLAMMATORY RESPONSE | TOLLLIKE RECEPTOR SIGNALING PATHWAY | |
|---|---|---|---|---|---|---|
| p-Value | 1.21 e-24 | 3.27 e-16 | 2.68 e-15 | 1.49 e-14 | 1.92 e-10 | |
| FDR q-Value | 7.11 e-22 | 9.59 e-14 | 5.24 e-13 | 2.19 e-10 | 1.87 e-8 | |
| k/K Value | 11/63 | 6/15 | 10/279 | 6/26 | 5/104 | |
| Cytokine symbol | IL-6 | |||||
| TNF-α | ||||||
| CCL-2/MCP-1 | ||||||
| CCL-3/ MIP-1α | ||||||
| G-CSF | ||||||
| CXCL-2/MIP-2 | ||||||
| MMP9 | ||||||
| CCL-4/MIP-1β | ||||||
| Pentraxin 3 | ||||||
| HGF | ||||||
| FGF acidic | ||||||
| IL-7 | ||||||
| CCL19/MIP-3β | ||||||
| CCL20/MIP-3α | ||||||
| IL-11 | ||||||
| CD40/TNFRSF5 | ||||||