Table 1.
Clinical characteristics before the observation period and when colchicine prescription was modified.
| Variable | Unexposed n = 9002 |
Exposed n = 406 |
Total N = 9408 |
Percentage difference |
|---|---|---|---|---|
| Women, n (%) | 6535 (72.59) | 203 (50) | 6738 (71.62) | |
| Age, median (IQR) | 60.84 (49.58, 74.36) | 67.83 (55.88, 78.64) | 61.16 (49.71,74.73) | |
| Diagnoses, n (%) | ||||
| Other inflammatory diseases | 2335 (25.94) | 64 (15.76) | 2399 | 64.59 |
| Rheumatoid arthritis | 1408 (15.64) | 36 (8.87) | 1444 | 76.32 |
| Knee osteoarthritis | 619 (6.88) | 55 (13.55) | 674 | 49.23 |
| Hand osteoarthritis | 450 (5) | 80 (20.69) | 534 | 75.83 |
| Monoarthritis | 95 (1.06) | 24 (5.91) | 119 | 82.06 |
| Behçet’s disease | 19 (0.21) | 23 (5.67) | 42 | 96.3 |
| Gout | 200 (2.22) | 195 (48.03) | 395 | 95.38 |
| Treatment, n (%) | ||||
| Analgesic | 1900 (21.11) | 57 (14.04) | 1957 | 50.36 |
| NSAIDs | 1303 (14.47) | 34 (8.37) | 1337 | 72.88 |
| DMARDs | 1047 (11.63) | 34 (8.37) | 1081 | 38.95 |
| Corticosteroid oral | 862 (9.58) | 78 (19.21) | 940 | 50.13 |
| Comorbidities, n (%) | ||||
| Hypertension | 2138 (23.75) | 130 (32.02) | 2268 | 25.83 |
| Dyslipidemia | 1840 (20.44) | 93 (22.91) | 1933 | 10.78 |
| Thyroid disease | 862 (9.58) | 35 (8.62) | 896 | 10.9 |
| Diabetes mellitus | 714 (7.93) | 35 (8.62) | 749 | 8 |
| Cancer | 664 (7.38) | 36 (8.87) | 700 | 16.8 |
| Vascular disease | 527 (5.85) | 47 (11.58) | 574 | 49.48 |
| Lung disease – ILD/COPD | 459 (5.1) | 28 (6.9) | 487 | 26.09 |
| Cardiovascular disease | 401 (4.45) | 31 (7.64) | 432 | 41.75 |
| Rosser index, median (IQR)* | 0.99 (0.97, 0.99) | 0.99 (0.97, 0.99) | 0.99 (0.97, 0.99) | |
| Days from visit until the start of the study, median (IQR) | 73.00 (30.00, 115.00) | 66.00 (25.25, 104.00) | 73.00 (27.00, 115.00) | |
*
Rosser index was not used for data balancing.
COPD, chronic obstructive pulmonary disease; DMARD, disease-modifying anti-rheumatic drug; ILD, interstitial lung disease; IQR, interquartile range; NSAID, non-steroidal anti-inflammatory drug.