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. 2021 Mar 17;12:652045. doi: 10.3389/fendo.2021.652045

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Copyright © 2021 Negro, Verzicco, Tedeschi, Campanini, Zanelli, Negri, Farnetti, Nicoli, Palladini, Santi, Cunzi, Calvi, Coghi, Gerra, Volpi, Graiani and Cabassi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sections from right adrenal gland Morphologic analysis with hematoxylin-eosin staining in (A–D) at different magnification. Panels show a pheochromocytoma, with a typical zellballen pattern of growth (A, 20X), with perivascular cell cuffing around a blood vessel called pseudo-rosette pattern (B, 20X), with neoplastic cells inside vascular spaces (C, 20X), and at greater magnification (D, 40X), an atypical mitotic figure. Positive immunohistochemical staining of Chromogranin A in Panel (E), VIP (F) and anti-Somatostatin Receptor 2A (SSTR2A, H). Double immunostaining showing the co-expression of Chromogranin A (brown) and VIP (red) (G).