Fig. 2.

Pictorial representation of cholesterol transport in the human body. (A) Transport of dietary lipid in the form of TG, FFA, and cholesterol from the intestine to various organs, tissues, and cells. Dietary lipids or cholesterol are converted into chylomicrons with the help of bile acid. Chylomicrons shed TG & FFA, and the remaining chylomicron remnant containing cholesterol reaches the liver. (B) Reverse cholesterol transport from organs, tissues, or cells and back to the liver. Reverse cholesterol transport is mediated by HDL to remove excess cholesterol from different organs/tissue, small “c” represents cholesterol (C) Transport of TG, FFA, and cholesterol from the liver to other organs, tissues, and cells. The liver releases VLDLc consisting of different lipid components i.e., TG, FFA, and cholesterol. VLDLc shed TG & FFA forming IDLc and LDLc, cholesterol from LDLc is either used up by organs/tissue/cells or being taken up by the liver.