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Cholesterol biosynthesis pathway and its feedback mechanism. Cholesterol biosynthesis starts with the condensation of two acetyl CoA molecules into acetoacetyl CoA. (A) Cholesterol biosynthesis in normal cells is regulated through a negative feedback mechanism of cholesterol availability. (B) The cholesterol biosynthesis pathway in cancer cells is not/less regulated by cholesterol availability and stored as cholesterol ester with the help of enzymes like ACAT-1.
