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. 2021 Mar 30;40:114. doi: 10.1186/s13046-021-01895-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — CTD inhibits the migration and invasion of colon cancer cells. A wound-healing assay was performed to measure the effect of CTD on the migration of the CRC cell lines at 24 h. a Treatment with CTD remarkably inhibited the migratory ability of the CRC cells in a wound-healing assay. Scale bars, 100 μm. The representative images (up) and the summary bar chart (down) of the cells that migrated by ImageJ to calculate the area. b and c Transmembrane migration assay was performed to measure the effect of CTD at various concentrations on the migration and invasion of the CRC cells at 24 h. This result indicated that CTD suppresses migration and invasion. The data are shown as means ± SD of values from triplicate samples. (*p < 0.05, **p < 0.01, ***p < 0.001) indicate a significant difference compared to the control. d Protein expression of epithelial-mesenchymal transition (EMT) markers E-cadherin, N-cadherin, and vimentin levels were checked after CTD treatment and compared with control