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. 2021 Mar 31;21:141. doi: 10.1186/s12876-021-01723-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Tricellulin protein expression of human intestinal tissues. Mean value of Ctrl was set to 100%. a Combined scatter and bar plot of tricellulin of Ctrl, active UC (UC_Active), and remission UC (UC_Rem). In active patients, tricellulin was downregulated compared to Ctrl. Importantly, in remission of UC, the expression of tricellulin returned to the level of Ctrl (Ctrl: 100 ± 4.75%, n = 23; UC_Active: 60.22 ± 5.47%; UC_Rem: 100.69 ± 4.79%, n = 30, n = 6, **p < 0.01). b Representative western blots of tricellulin in Ctrl, UC_Rem and UC_Active. c Scatter and bar plot of Cldn-4 of Ctrl (100 ± 8.70%, n = 16), UC_Active (46.89 ± 9.03%, n = 6), and UC_Rem (107.63 ± 20.06%, n = 16). d Representative western blots of Cldn-4 in Ctrl, UC_Rem, and UC_Active. e Scatter and bar plot of angulin-1 of Ctrl (100 ± 12.24%, n = 18), UC_Active (61.45 ± 12.36%, n = 6, p = 0.2008) and UC_Rem (92.04 ± 14.49%, n = 18). f Representative western blots of angulin-1 from Ctrl, UC_Active and UC_Rem