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. 2021 Mar 31;12:221. doi: 10.1186/s13287-021-02290-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — The effect of IL-17RA silence on HSFs and excisional model of BALB/c mice. a The efficiency of IL-17RA siRNA in HSFs examined by immunofluorescence staining, scale bar = 50 μm. b qRT-PCR analysis of IL-17RA, Col1, and α-SMA in HSFs treated with IL-17RA siRNA or scramble siRNA. c Immunoblot analysis of IL-17RA, Col1, Col3, and α-SMA in HSFs exposed to IL-17RA siRNA or scramble siRNA, graphs showed the relative band density to β-actin. d, e The morphology of wound healing observed in different periods. Line chart showed the relative wound areas. f The trace of Lv-IL-17RA in wound tissues on day 5 detected by frozen sections, scale bar = 200 μm. g qRT-PCR analysis of IL-17RA, Col1, and α-SMA in wound tissues of BALB/c mice stimulated with mEGFP-NC or IL-17RA shRNA-EGFP, the graph represented their expression relative to that of GAPDH. h Immunoblot analysis of the aforementioned molecules. i Representative images showed the histopathological change, collagen deposition, and positive α-SMA+ fibroblasts determined by H&E, Masson’s trichrome, and immunohistochemistry staining, respectively, scale bar = 400 μm, 100 μm, 50 μm. The data was shown as mean ± SEM (*p < 0.05; **p < 0.01)