Table 3.
Associations of delayed graft function and other clinical characteristics with change in peritubular capillary density in the fully adjusted multivariable model (n=191)
| Clinical Characteristics | Mean Change, % (SD) | Unadjusted Difference in Change, % (95% Confidence Interval) | P Value | Difference in Change Adjusted only for Pretransplant Peritubular Capillary Density, % (95% Confidence Interval) | P Value | Fully Adjusted Difference in Change, % (95% Confidence Interval)a | P Value |
|---|---|---|---|---|---|---|---|
| Postoperative graft function | 0.60 | <0.001 | <0.001 | ||||
| Immediate graft function | −4.6 (5.2) | 0 | 0 | 0 | |||
| Delayed graft function | −3.9 (4.1) | 0.5 (−1.4 to 2.5) | −3.4 (−4.4 to −2.4) | −2.9 (−4.0 to −1.8) | |||
| Peritubular capillary density on the preimplantation biopsy, per 1% higher | −0.8 (−0.9 to −0.8) | <0.001 | −0.8 (−0.9 to −0.8) | <0.001 | −0.9 (−1.0 to −0.9) | <0.001 | |
| Donor type | |||||||
| Neurologically deceased | −3.4 (4.9) | 0 | 0 | 0 | |||
| Living | −6.3 (4.5) | −2.8 (−4.3 to −1.3) | <0.001 | 0.7 (−0.2 to 1.6) | 0.13 | −0.0 (−1.0 to 0.9) | 0.97 |
| Cardiocirculatory arrest | −4.3 (4.2) | −1.0 (−3.2 to 1.3) | 0.41 | −0.6 (−1.8 to 0.7) | 0.39 | 0.3 (−1.0 to 1.5) | 0.67 |
| Donor age per 10 yr higher | −0.2 (−0.7 to 0.2) | 0.29 | −0.2 (−1.6 to 0.2) | 0.11 | −0.1 (−0.4 to 0.1) | 0.33 | |
| Rejection | 0.25 | 0.12 | 0.74 | ||||
| Absence of rejection | −4.2 (5.1) | 0 | 0 | 0 | |||
| Rejection | −5.2 (4.0) | −1.0 (−2.7 to 0.7) | −0.7 (−1.3 to 1.5) | −0.2 (−1.0 to 0.7) | |||
| Donor BP | 0.47 | 0.003 | 0.02 | ||||
| Normal BP | −4.5 (4.9) | 0 | 0 | 0 | |||
| Donor hypertension | −3.8 (4.6) | 0.7 (−1.2 to 2.6) | −1.6 (−2.6 to −0.5) | −1.2 (−2.2 to −0.2) | |||
| Recipient statin use | 0.90 | 0.15 | 0.19 | ||||
| No statin use at transplant | −4.3 (4.9) | 0 | 0 | 0 | |||
| Statin at time of transplant | −4.4 (4.8) | −0.1 (−1.5 to 1.3) | 0.6 (−0.2 to 1.3) | 0.5 (−0.2 to 1.1) | |||
| Biopsy type | 2.2 (−0.3 to 4.7) | 0.07 | 2.3 (1.0 to 3.6) | <0.001 | 1.5 (0.2 to 2.7) | 0.02 | |
| For cause | −6.8 (3.6) | ||||||
| Surveillance | −4.2 (4.9) | ||||||
| KRT before transplantation | 0.77 | 0.05 | 0.19 | ||||
| Dialysis pretransplant | −4.3 (4.8) | 0 | 0 | 0 | |||
| Preemptive transplantation | −4.9 (5.5) | −0.3 (−2.4 to 1.7) | 1.1 (−0.0 to 1.2) | 0.7 (−0.4 to 1.7) | |||
| Modality of graft transportation | 0.03 | 0.02 | 0.14 | ||||
| Cold storage | −5.1 (4.7) | 0 | 0 | 0 | |||
| Hypothermic perfusion | −3.7 (4.9) | 1.6 (0.2 to 2.9) | 0.9 (0.1 to 1.6) | 0.5 (−0.2 to 1.3) | |||
| cv score on the pretransplant biopsy, per 1 point higher | 0.2 (−0.6 to 1.0) | 0.62 | 0.7 (−0.1 to 1.4) | 0.09 | 0.6 (−0.2 to 1.3) | 0.12 | |
| Time to post-transplant biopsy, per 1 mo higher | 0.2 (−0.3 to 0.7) | 0.42 | 0.3 (0.1 to 0.6) | 0.01 | 0.0 (−0.2 to 0.3) | 0.85 |
cv, Banff score for vascular fibrous intimal thickening.
a
In addition to the variables included in the table, estimates are adjusted for biopsy size to correct for technical variations in measurement.