Table 4.
Factors associated with eGFR 1 year post-transplant
| Clinical Characteristics | Mean Change, ml/min per 1.73 m2 (SD) | Unadjusted Difference, ml/min per 1.73 m2 (95% Confidence Interval) | P Value | Adjusted Difference without Delayed Graft Function, ml/min per 1.73 m2 (95% Confidence Interval)a | P Value | Adjusted Difference with Delayed Graft Function, ml/min per 1.73 m2 (95% Confidence Interval)a | P Value |
|---|---|---|---|---|---|---|---|
| Pretransplant peritubular capillary density per 1% higher | 0.6 (0.1 to 1.0) | 0.01 | 1.3 (0.6 to 2.0) | <0.001 | 1.0 (0.1 to 1.9) | 0.03 | |
| Peritubular capillary change per 1% higher | 0.0 (−0.4 to 0.5) | 0.92 | 1.0 (0.3 to 1.8) | 0.007 | 0.8 (−0.1 to 1.6) | 0.07 | |
| Postoperative graft function | <0.001 | not included | 0.23 | ||||
| Immediate graft function | 60.7 (15.6) | 0 | 0 | ||||
| Delayed graft function | 51.1 (13.1) | −9.2 (−13.7 to −4.6) | −3.1 (−8.3 to 2.0) | ||||
| Biopsy type | <0.001 | 0.005 | 0.004 | ||||
| For cause | 43.9 (15.7) | 0 | 0 | 0 | |||
| Surveillance | 59.0 (14.8) | 15.7 (8.6 to 22.8) | 10.5 (3.3 to 17.7) | 10.7 (3.5 to 17.0) | |||
| Donor sex | 0.001 | 0.005 | 0.004 | ||||
| Man donor | 61.7 (15.7) | 0 | 0 | 0 | |||
| Woman donor | 54.1 (14.4) | −7.5 (−11.8 to −3.3) | −5.8 (−9.8 to −1.8) | −5.9 (−9.9 to −1.9) | |||
| Donor BP | 0.01 | 0.19 | 0.17 | ||||
| Normal BP | 58.9 (15.8) | 0 | 0 | 0 | |||
| Donor hypertension | 51.7 (11.4) | −7.6 (−13.6 to −1.6) | −3.7 (−9.3 to 1.9) | −3.9 (−9.5 to 1.7) | |||
| Donor age per 10 yr higher | −2.6 (−4.2 to −1.0) | <0.001 | −1.0 (−2.6 to −0.7) | 0.24 | −1.0 (−2.7 to 0.1) | 0.21 | |
| Glomerulosclerosis on the pretransplant biopsy per 1% higher | −0.7 (−1.1 to −0.3) | 0.001 | −0.6 (−1.1 to −0.1) | 0.01 | −0.6 (−1.1 to −0.1) | 0.02 | |
| ci score on the pretransplant biopsy per 1 point higher | −3.0 (−7.0 to 1.0) | 0.14 | 1.9 (−2.6 to 6.4) | 0.41 | 2.1 (−2.4 to 6.6) | 0.36 | |
| No. of previous transplants | 0.13 | 0.44 | 0.51 | ||||
| First transplants | 58.4 (15.7) | 0 | 0 | 0 | |||
| Repeated transplants | 53.3 (12.5) | −5.1 (−11.7 to 1.5) | −2.3 (−8.2 to 3.6) | −2.0 (−7.9 to 3.9) | |||
| Cause of CKD | 0.03 | 0.03 | 0.03 | ||||
| Other | 55.9 (15.4) | 0 | 0 | 0 | |||
| Glomerular diseases | 60.8 (15.0) | 4.9 (0.4 to 9.4) | 4.6 (0.5 to 8.7) | 4.7 (0.6 to 8.8) |
ci, Banff score for interstitial fibrosis.
a
All of the variables included in the multivariable model are listed in the table.