Figure 1.

Complex determination of immune-mediated glomerular injury involves interactions of genetic risk loci with environmental exposures. The genetic factors are listed in yellow boxes and include high-priority candidate genes at genome-wide significant loci; potential environmental disease triggers are listed in green boxes. Schematic representations of histopathologic injury patterns for IgA nephropathy, membranous nephropathy, and steroid-sensitive nephrotic syndrome (SSNS) are also provided. URIs, upper respiratory infections.