Table 2.
Differences in characteristics of quartiles of kidney transplantations in Finland from June 2004 to December 2017 and the United States from January 2008 to August 2008 by quartiles of time from brain death to organ perfusion (procurement delay)
| Variable | Finland: Quartiles of Time from Brain Death to Organ Perfusion in Organ Donors | United States: Quartiles of Time from Brain Death to Organ Perfusion in Organ Donors | ||||||
|---|---|---|---|---|---|---|---|---|
| Quartile, n of donors, n of recipients | First, n: 321, n: 596 | Second, n: 326, n: 598 | Third, n: 330, n: 597 | Fourth, n: 334, n: 597 | First, n: 14,689, n: 25,366 | Second, n: 14,686, n: 25,371 | Third, n: 14,711, n: 25,369 | Fourth, n: 14,706, n: 25,368 |
| Time from brain death to organ perfusion, median (IQR), h | 6.5 (5.8–7.2) | 8.7 (8.2–9.1) | 10.8 (10.2–11.5) | 15.1 (13.5–18.0) | 20.5 (16.1–23.8) | 30.6 (28.5–32.7) | 39.6 (37.1–42.6) | 57.1 (50.9–67.1) |
| KDPI, median (IQR), % | 76 (55–89) | 63 (43–81) | 57 (34–79) | 43 (23–62) | 53 (25–77) | 45 (20–69) | 41 (19–66) | 37 (17–62) |
| Donor age, median (IQR), yr | 61 (54–67) | 56 (47–63) | 53 (40–61) | 48 (37–56) | 43 (26–55) | 37 (23–50) | 35 (22–48) | 34 (22–47) |
| Donor BMI, median, kg/m2 | 25.7 (23.9–27.8) | 25.0 (23.3–27.6) | 24.7 (22.9–27.7) | 24.5 (22.9–27.5) | 26.4 (22.8–30.9) | 26.0 (22.4–30.6) | 26.0 (22.5–30.4) | 25.9 (22.5–30.2) |
| Donor creatinine, median, mg/dl | 0.68 (0.55–0.81) | 0.67 (0.53–0.80) | 0.63 (0.50–0.80) | 0.64 (0.53–0.80) | 1.00 (0.71–1.36) | 1.00 (0.70–1.30) | 1.00 (0.70–1.33) | 0.99 (0.70–1.40) |
| Donor hypertension | 125 (39%) | 98 (30%) | 82 (25%) | 72 (22%) | 4741 (32%) | 3948 (27%) | 3589 (25%) | 3203 (22%) |
| Donor cause of death: Cerebrovascular accident | 236 (74%) | 227 (70%) | 221 (67%) | 211 (63%) | 5367 (37%) | 4675 (32%) | 4189 (29%) | 3909 (27%) |
| Donor resuscitated | 53 (17%) | 60 (18%) | 56 (17%) | 60 (18%) | 1149 (8%) | 1142 (8%) | 1122 (8%) | 1014 (7%) |
| Donor diabetes | 23 (7%) | 15 (5%) | 6 (2%) | 13 (4%) | 1292 (9%) | 1028 (7%) | 903 (6%) | 808 (6%) |
| Donor organ yield,a median | 2 (2–2) | 3 (2–3) | 3 (2–3) | 3 (2–4) | 3 (2–4) | 3 (3–4) | 4 (3–5) | 4 (3–5) |
| Cold ischemia time, median, h | 20.9 (18.1–23.6) | 20.6 (18.0–23.8) | 20.3 (16.9–23.3) | 19.4 (14.5–22.9) | 16.3 (10.8–23.0) | 16.0 (11.1–21.1) | 14.1 (9.7–21.2) | 15.5 (10.2–21.5) |
| Recipient age, median, yr | 57 (48–65) | 54 (42–62) | 51 (40–60) | 48 (37–58) | 56 (45–64) | 54 (42–63) | 53 (41–62) | 52 (40–62) |
| Recipient diabetes | 147 (25%) | 165 (28%) | 162 (27%) | 185 (31%) | 9232 (36%) | 8594 (34%) | 8315 (33%) | 8167 (32%) |
| HLA MM total, median | 3 (2–3) | 3 (2–3) | 3 (2–3) | 3 (2–3) | 4 (3–5) | 4 (3–5) | 4 (3–5) | 4 (3–5) |
| Previous kidney transplant | 65 (11%) | 58 (10%) | 64 (11%) | 62 (10%) | 2960 (12%) | 3204 (13%) | 3481 (14%) | 3663 (14%) |
| Donor Black | NA | NA | NA | NA | 1987 (14%) | 2405 (16%) | 2634 (18%) | 2655 (18%) |
| Recipient Black | NA | NA | NA | NA | 8737 (34%) | 8499 (34%) | 8421 (33%) | 7545 (30%) |
| Recipient BMI, median, kg/m2 | 25.5 (22.7–28.5) | 25.2 (22.1–28.1) | 24.8 (22.3–28.0) | 24.3 (21.6–28.1) | 27.6 (23.9–31.7) | 27.5 (23.6–31.7) | 27.3 (23.5–31.6) | 27.1 (23.3–31.3) |
| Recipient time in dialysis, mo, median (IQR) | 23 (15–38) | 23 (14–38) | 22 (12–38) | 19 (12–36) | 43 (23–67) | 43 (23–69) | 46 (23–74) | 51 (25–83) |
Time from brain death to organ perfusion: time from declaration of brain death to in situ organ cold perfusion. Kidney Donor Profile Index (KDPI) is calculated from donor age, height, weight, history of diabetes and hypertension, cause of death, creatinine, and race. IQR, interquartile range; BMI, body mass index; MM, mismatch; NA, not available.
a
Organ yield from multiorgan donor: maximum of seven (heart, lungs, liver, pancreas, intestine, and two kidneys).