TABLE 3.

Association between both cognitive status and length of time worked on the WTC site and hippocampal subfield volumes

	Panel A: Standardized regression coefficients showing size of cognitive impairment association			Panel B: Standardized regression coefficients showing size of association with total months on site
Subregion name	β	SE	P	β	SE	P
CA1	–0.10	0.086	0.245	–0.16	0.087	0.148
CA2/3	–0.11	0.087	0.218	0.09	0.088	0.333
CA4	–0.22	0.084	0.031*	–0.07	0.085	0.394
CG‐DG	–0.21	0.083	0.031*	–0.1	0.084	0.333
ML	–0.18	0.083	0.056	–0.2	0.084	0.045*
Subiculum	–0.18	0.086	0.056	–0.24	0.087	0.031*
Presubiculum	–0.28	0.085	0.013*	–0.29	0.086	0.0095**
Fimbria	–0.19	0.097	0.074	–0.11	0.098	0.333

Notes: Regression models included both cognitive impairment and total time worked at the WTC site (months) simultaneously as predictors were used to test associations with hippocampal subfield volumes adjusted for TIV. Resulted standardized beta coefficients (β) represent the change in standard deviation units of subregion volume associated with CI (Panel A) and length of time worked on the WTC site (Panel B). P‐values (P) were corrected for false discovery rate. *P < 0.05 and **P < 0.01.

Abbreviations: β, standardized beta coefficient; CA, cornu ammonis; CG‐DG, granule cell layer of dentate gyrus; CI, WTC responders with cognitive impairment; CU, WTC responders with unimpaired cognition; ML, molecular layer; se, standard error for the standardized coefficient; TIV, total intracranial volume; WTC, World Trade Center.