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. 2021 Mar 31;11:63. doi: 10.1186/s13578-021-00575-8

Fig. 4.

Fig. 4

Targeting PD-L1 affected TMZ-resistance in both TS-GBM and TR-GBM cells. By performing the Annexin V-FITC/PI double staining assay, cell apoptosis ratio was determined. a PD-L1 was upregulated in TS-GBM cells, and the results indicated that PD-L1 overexpression increased TMZ-resistance in TS-GBM cells. b Knock-down of PD-L1 enhanced TMZ-sensitivity in TR-GBM cells. Each experiment had at least 3 repetitions, and *P < 0.05