Table 2.
Diagnostic efficiency of multiparametric ultrasound (grayscale ultrasound, PD and GIS) at real-time evaluation for the prediction of endometrial cancer in patients with post-menopausal bleeding and endometrial thickness≥4 mm
| AUC | Correctly classified% | Sensitivity | Specificity | LR+ | LR– | |
|---|---|---|---|---|---|---|
| (95% CI) | % | % | ||||
| Grayscale ultrasound | ||||||
| ET ≥ 14.6 | 0.767 (0.70–0.85) | 76.8 | 61.7 | 92.2 | 6.6 | 0.44 |
| Heterogeneous echogenicity | 0.582 (0.52–0.64) | 53.2 | 86.1 | 74.9 | 1.3 | 0.52 |
| Non-cystic echogencity | 0.634 (0.570.72) | 62.1 | 72.3 | 53.9 | 1.4 | 0.56 |
| Irregular endomyometrial junction | 0.733 (0.77–0.80) | 73.1 | 74.2 | 70.9 | 2.4 | 0.39 |
| Iintrupted endomyometrial junction | 0.781 (0.72–0.85) | 81.2 | 61.4 | 93.9 | 11.1 | 0.43 |
| Non-intact endomyometrial junction | 0.791 (0.74–0.87) | 82.1 | 63.4 | 96.1 | 13.2 | 0.42 |
| GIS | ||||||
| ET ≥ 12.8 | 0.811 (0.73–0.89) | 76.9 | 77.8 | 77.2 | 3.5 | 0.31 |
| Iintrupted endomyometrial junction | 0.811 (0.79–0.85) | 84.1 | 72.2 | 95.3 | 11.9 | 0.33 |
| Non-intact endomyometrial junction | 0.866 (0.75–0.90) | 85.1 | 72.9 | 95.1 | 13.1 | 0.33 |
| Irregular endometrial surface | 0.799 (0.75–0.82) | 79.3 | 82.2 | 76.4 | 3.6 | 0.24 |
| PD | ||||||
| Color Doppler | ||||||
| (No flow/ minimal flow) | 0.588 (0.55–0.70) | 52.1 | 92.1 | 28.3 | 1.2 | 0.29 |
| (Moderate/abundant flow) | 0.765 (0.69–0.82) | 76.1 | 69.2 | 82.1 | 3.4 | 0.39 |
| Vascular pattern | ||||||
| Single dominant vessel ± branching | 0.755 (0.62–0.83) | 73.9 | 65.2 | 81.1 | 3.5 | 0.41 |
| Multiple dominant vessel ± branching | 0.677 (0.61–0.80) | 70 | 69.1 | 68.9 | 2.1 | 0.49 |
| 0.42 | ||||||
| Scattered vessels | 0.811 (0.71–0.88) | 84.1 | 62.2 | 91.9 | 8.2 | |
| 0.6 | ||||||
| Areas with densely packed or color-splash vessels | 0.802 (0.65–0.81) | 76.2 | 49.9 | 94.1 | 7.6 |
AUC, area under the curve; CI, confidence interval; GIS, gel infusion sonography; LR, likelihood ratio; PD, power Doppler.