Figure 3.

GDC-0941 treatment significantly decreases OAC tumour growth in vivo. (a) SCID-Beige female mice bearing OE33 tumour xenografts were treated bd with GDC-0941 (50 mg/kg) or vehicle control via oral gavage for 8 days. Data represent the average mean tumour volume of n = 3 (treated) or n = 3 (vehicle) animals per treatment group. (b) Animals were sacrificed 1 h after the final treatment dose and tAKT/ pAKT protein levels assessed by Western blot. Western blot is representative of n = 3 repeats. Error bars represent mean ± SEM. *p < 0.05. OAC, oesophagealadenocarcinoma; SEM, standard error of the mean.