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. 2021 Apr 2;128(7):1040–1061. doi: 10.1161/CIRCRESAHA.121.318051

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© 2021 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 1. — The interplay between cancer and hypertension. Cancer and hypertension frequently occur in the same patients, which is partly attributable to common risk factors and overlapping pathophysiological mechanisms for both conditions, including an increased body mass index (BMI), diabetes, inflammation, and oxidative stress. Furthermore, various anticancer therapies and adjunctive therapies exert prohypertensive effects, predisposing cancer patients to the development of hypertension. This risk could be further increased due to cancer-associated factors, such as inadequate pain control and anxiety. A direct relationship between hypertension and renal cell carcinoma has been proposed, but this has not been verified for other malignancies. Eventually, this interplay contributes to the elevated cardiovascular risk observed in patients with cancer.