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. 2021 Mar 31;10:25. doi: 10.1186/s40164-021-00218-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Construction of HCC cell lines with overexpression or downregulation of PCSK9. a Relative mRNA expression level of PCSK9 in HCC cell lines and a normal hepatocyte cell line (L02). b Transfection efficiency of PCSK9-overexpressing virus in the HCCLM3 cell line. c Transfection efficiency of PCSK9-knockdown virus in the HepG2 cell line. d Relative mRNA expression level of PCSK9 in the HCCLM3 cell line (p < 0.001). e Western blot images and summarized data showing that PCSK9 was successfully overexpressed in the HCCLM3 cell line (p = 0.014). f Relative mRNA expression level of PCSK9 in the HepG2 cell line (p = 0.004). g Western blot images and summarized data showing that PCSK9 was successfully downregulated in the HepG2 cell line (p = 0.001). *p < 0.05, **p < 0.01, ***p < 0.001