Table 2.

Intercept, residual SE, and change in level and trend after lockdown was imposed with corresponding p values (compared with average of last 4 years, the control group)

Cohort	Intercept	Change in level after intervention	Change in trend after intervention	Residual SE
All patients, n=100 165	0.833*	−0.196 (0.0077)	0.029 (0.0536)	0.082
Stratification by healthcare setting
Resolved within primary care	0.913*	−0.244*	−0.022 (0.0001)	0.032
Hospital	0.134*	−0.005 (0.7894)	0.004 (0.1149)	0.014
Stratification of population cohort by sex†
Men, n=39 673	0.976*	−0.210*	−0.009 (0.0068)	0.035
Women, n=60 360	1.090*	−0.277*	−0.024 (0.0015)	0.042
Stratification of population cohort by age (years)
0–5, n=1407	0.839*	−0.367 (0.0013)	−0.009 (0.5175)	0.127
5–17, n=10 739	0.618*	−0.159 (0.0328)	−0.005 (0.6351)	0.061
18–54, n=43 740	0.919*	−0.238 (0.0010)	−0.037 (0.0004)	0.059
≥55, n=44 279	1.305*	−0.241*	0.002 (0.7942)	0.041
Stratification of population cohort by region
East England, n=21 002	1.067*	−0.283*	−0.014 (0.0307)	0.048
East Midlands, n=4483	0.787*	−0.371*	−0.037 (0.0003)	0.083
London, n=3302	0.639*	−0.261 (0.0702)	−0.004 (0.8451)	0.133
North East, n=4985	1.205*	−0.068 (0.6176)	−0.025 (0.1845)	0.108
North West, n=12 456	1.186*	−0.258 (0.0147)	−0.060 (0.0001)	0.089
South East, n=20 445	1.030*	−0.261*	0.000 (0.9582)	0.051
South West, n=14 378	1.049*	−0.275*	−0.010 (0.0028)	0.050
West Midlands, n=1874	1.383*	−0.590 (0.0031)	−0.146*	0.191
Yorkshire and the Humber, n=17 240	0.989*	−0.132 (0.0235)	−0.011 (0.1555)	0.048

*P<0.0001.

†A total of 132 patients did not have sex information in the database.