Table 4.

Attributes of pandemic-related missing data.

Missing endpoint measurement	Assessment missing due to a participant’s premature discontinuation from the study overall for pandemic-related reasons; Assessment missing due to missed study visits/procedures while a participant remains in the study (intermittent missing data); Assessment delayed (out-of-window) and deemed unusable for an analysis; A composite score (e.g., ACR20 in rheumatoid arthritis) cannot be calculated because some components are missing; Assessment deemed to be influenced by pandemic-related factors and deemed unusable for a particular analysis because the interpretability of the results may be impacted (e.g., in assessments of quality of life, activity/functional scales, healthcare utilization, etc.); Recorded data cannot be properly verified or adjudicated due to COVID-19-related factors and deemed to be unreliable for analysis; Assessment performed after an intercurrent event intended to be handled with a hypothetical strategy and collected data are deemed unusable for this estimand.
Assessment accessibility	Site (facilities or staff) unavailable to perform study-related assessments; Site/assessment procedure available but participant is unable/unwilling to get assessment done due to personal pandemic-related reasons.
Participant’s COVID-19 infection condition	Participant positive for COVID-19 and alive; Participant deceased due to COVID-19; Participant without a known COVID-19 infection.
Participant’s COVID-19 concomitant treatment(s)	Participants treated for COVID-19 (pharmacologically, oxygen, etc.); Hospitalized, not in intensive care; Admitted to intensive care.

NOTE: Row 1 summarizes reasons of missing data, rows 2–4 summarize related conditions that contribute to those reasons.