. 2021 Feb 5;36(3):154–161. doi: 10.1097/YIC.0000000000000351

Table 2.

Effectiveness outcomes and overall effectiveness

Outcome measure	Baseline, mean (SE)	Final visit, mean (SE)	LSM change (SE)
SAND, total score	18.1 (0.5)	11.9 (0.6)	MMRM	−7.3 (0.5)^a
SAND, total score	18.1 (0.5)	11.9 (0.6)	LOCF	−6.2 (0.4)^a
SAND, positive score	1.6 (0.2)	1.0 (0.2)	MMRM	−0.9 (0.2)^a
SAND, positive score	1.6 (0.2)	1.0 (0.2)	LOCF	−0.6 (0.1)^a
Hallucinations	0.7 (0.1)	0.4 (0.1)	–	–
Delusions	0.9 (0.1)	0.6 (0.1)	–	–
SAND, negative score	16.5 (0.4)	10.9 (0.5)	MMRM	−6.3 (0.5)^a
SAND, negative score	16.5 (0.4)	10.9 (0.5)	LOCF	−5.6 (0.3)^a
Anhedonia	3.2 (0.1)	2.1 (0.1)	–	–
Blunted affect	3.4 (0.1)	2.4 (0.1)	–	–
Avolition/apathy	3.5 (0.1)	2.2 (0.1)	–	–
Alogia	2.8 (0.1)	1.9 (0.1)	–	–
Asociality	3.5 (0.1)	2.3 (0.1)	–	–
CGI-I score	–	2.9 (0.1)	MMRM	2.6 (0.1)^a
CGI-I score	–	2.9 (0.1)	LOCF	2.9 (0.1)^a
CGI-S score	4.4 (0.1)	3.7 (0.1)	MMRM	−0.9 (0.1)^a
CGI-S score	4.4 (0.1)	3.7 (0.1)	LOCF	−0.7 (0.1)^a
Physicians’ impression about overall effectiveness		Final visit, n (%)
Very satisfied		37 (31.9)
Satisfied		47 (40.5)
Neutral		22 (19.0)
Dissatisfied		10 (8.6)
Very dissatisfied		–

CGI-I, clinical global impressions-improvement; CGI-S, clinical global impressions-severity; LOCF, last observation carried forward; LSM, least squares mean; MMRM, mixed-effects model for repeated measures; SAND, short assessment of negative domains.

<0.001.