. Author manuscript; available in PMC: 2021 Oct 1.

Published in final edited form as: Small Struct. 2020 Sep 9;1(1):2000018. doi: 10.1002/sstr.202000018

Table 3.

Summary of direct binding between bacteria and platelet.

Bacterial pathogens	Bacterial proteins	Platelet receptors and bridging proteins	Reference
Staphylococcus aureus	ClfA	fibrinogen, GPIIb/IIIa, FcγRIIa, IgG, gC1q-R/P32	[98]
	ClfB	fibrinogens, GPIIb/IIIa, FcγRIIa, IgG, gC1q-R/P32	[93]
	SpA	GPIb, vWF, gC1q-R/P32	[91, 92]
	FnBPA and FnBPB	fibrinogen, fibronectin, GPIIb/IIIa, FcγRIIa, IgG	[94, 98, 99]
	SdrE	complement, IgG	[100]
	SraP	GPIb	[86]
	IsaB	GPIIb/IIIa	[89]
Staphylococcus epidermidis	SdrG	fibrinogen, GPIIb/IIIa, FcγRIIa, IgG	[88]
Streptococcus sanguis	SrpA	GPIb, vWF, FcγRIIa	[23, 85]
Streptococcus agalactiae	FbsA	fibrinogen, IgG, GPIIb/IIIa	[96, 97]
Streptococcus pyogenes	M protein	FcγRIIa, GPIIb/IIIa, fibrinogen	[95]
Streptococcus gordonii	GspB/HsA	GPIb	[84]
Streptococcus gordonii	PadA	GPIIb/IIIa	[90]
Porphyromonas gingivalis	Hgp	GPIb	[87]

ClfA, B: clumping factor A, B; SpA: surface protein A; FnBPA, B: fibronectin-binding protein A, B; IgG, immunoglobulin G; IsaB: Immunodominant surface antigen B; SdrE, G: serine-aspartate repeat protein E, G; SrpA: serine-rich protein A; FbsA: fibrinogen-binding protein from Streptococcus agalactiae; GspB: glycosylated streptococcal protein B; HsA: hemagglutinin salivary antigen; PadA: platelet adherence protein A; Hgp: high molecular mass gingipain.