Table 1.
Genes were up-regulated 5 folds or more by androgen (MENT).
| Ontogeny | Gene symbol | Arbitrary count | |||
|---|---|---|---|---|---|
| Control | MENT | LH | LH+MENT | ||
| Cell cycle | Cdkn1a | 20 | 160(+8) | 161(+8) | 178(+8) |
| Cytokine | Cxcl2 | 119 | 1250(+10) | 5927(+50) | 1157(+10) |
| Il6 | 75 | 644(+9) | 1560(+21) | 415(+6) | |
| Extracellular matrix | Serpine1 | 1012 | 4982(+5) | 8862(+9) | 5070(+5) |
| Cyr61 | 536 | 2581(+5) | 5088(+10) | 11970(+4) | |
| Tfpi2 | 123 | 669(+5) | 1706(+14) | 539(+4) | |
| Timp3 | 63 | 319(+5) | 133(+2) | 211(+3) | |
| Growth arrest | Errfi1 | 688 | 6335(+9) | 3362(+5) | 2667(+4) |
| Gadd45g | 122 | 2071(+17) | 488(+4) | 689(+6) | |
| GTP binding | Arl5b | 56 | 431(+8) | 251(+4) | 262(+5) |
| Metabolism | Ptgs2 | 2160 | 14724(+7) | 25443(+12) | 10581(+5) |
| Cyp26b1 | 513 | 2680(+5) | 1522(+3) | 1618(+3) | |
| Aldh5a1 | 116 | 653(+6) | 193(+2) | 401(+3) | |
| Ero1l | 162 | 876(+5) | 583(+4) | 491(+3) | |
| Protein binding | Cldn1 | 73 | 405(+5) | 158(+2) | 166(+2) |
| Growth factor | Fgl2 | 247 | 1653(+7) | 297(+1.2) | 523(+3) |
| Adm | 281 | 3202(+11) | 2730(+10) | 2025(+7) | |
| Ctgf | 45 | 521(+12) | 1237(+27) | 232(+5) | |
| Adora2a | 765 | 4103(+5) | 4143(+5) | 3132(+4) | |
| Gdf15 | 180 | 925(+5) | 995(+5) | 830(+5) | |
| Signaling | Csf3 | 34 | 181(+5) | 1306(+39) | 273(+8) |
| Pim1 | 31 | 355(+11) | 166(+5) | 196(+6) | |
| Rgs4 | 43 | 418(+10) | 674(+16) | 291(+7) | |
| Ppp1r3b | 61 | 427(+7) | 232(+4) | 396(+6) | |
| Steroidogenesis | Cyp17a1 | 288 | 1082(+5) | 600(+2) | 574(+2) |
| Transcription factor | Bhlhb3 | 217 | 1781(+8) | 1081(+5) | 1194(+5) |
| Atf3 | 102 | 619(+6) | 648(+6) | 382(+3) | |
| Hig1 | 260 | 1438(+6) | 1276(+5) | 914(+4) | |
| Mxd1 | 16 | 243(+15) | 237(+15) | 272(+17) | |
| Bhlhb2 | 1248 | 6539(+5) | 3926(+3) | 4554(+4) | |
| Bhlhb3 | 182 | 1745(+10) | 1044(+6) | 1158(+6) | |
| Btg2 | 423 | 2116(+5) | 3114(+7) | 1552(+4) | |
| Transporter | Slc40a1 | 295 | 2225(+7) | 306(+1) | 624(+2) |
| Atp2b3 | 96 | 597(+5) | 76(-0.9) | 140(+1.4) | |
| Slc2a3 | 26 | 193(+7) | 153(+6) | 147(+6) | |
() Fold changes after MENT, LH or LH+MENT compared to control. 35 Genes examined, of them, the expression of 32 genes were up-regulated by 2 folds or higher by LH treatment.