Table 2.
Predictions of human PK parameters for intravenous cisplatin obtained with the multi-Organ Chip IVIVT platform compared to clinical values and rodent clearance results.
| Cisplatin PK Parameters (systemic compartment) |
Human (Clinical data) |
In Silico Model (Multi-Organ Chips) |
|---|---|---|
| Cisplatin (1 hour infusion) | ||
| Cmax (μM) | 18.02±4.93 | 22.72 (δ=26,1 %, p=0.0146) |
|
tmax (min) (Range: minimum – maximum) |
~1.0 | 1.0 |
| AUC (μM.hr) | 41.94±12.41 | 48.27 (δ=15.1 %, n.s.) |
| Cisplatin (3 hour infusion) | ||
| Cmax (μM) | 30.30±6.48 | 37.26 (δ=23.0 %, p=0.0079) |
|
tmax (min) (Range: minimum – maximum) |
~3.0 | 3.0 |
| AUC (μM.hr) | 253.33±100.32 | 252.6 (δ=0,4 %, n.s.) |
*
In vivo human clinical data Rajkumar et al. 39
**
AUC was computed for times when clinical measurements were available for both in vivo and in silico studies