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. Author manuscript; available in PMC: 2021 Mar 31.
Published in final edited form as: Nat Biomed Eng. 2020 Jan 27;4(4):421–436. doi: 10.1038/s41551-019-0498-9

Table 2.

Predictions of human PK parameters for intravenous cisplatin obtained with the multi-Organ Chip IVIVT platform compared to clinical values and rodent clearance results.

Cisplatin PK Parameters
(systemic compartment)
Human
(Clinical data)
In Silico Model
(Multi-Organ Chips)
Cisplatin (1 hour infusion)
Cmax (μM) 18.02±4.93 22.72 (δ=26,1 %, p=0.0146)
tmax (min)
(Range: minimum – maximum)
~1.0 1.0
AUC (μM.hr) 41.94±12.41 48.27=15.1 %, n.s.)
Cisplatin (3 hour infusion)
Cmax (μM) 30.30±6.48 37.26=23.0 %, p=0.0079)
tmax (min)
(Range: minimum – maximum)
~3.0 3.0
AUC (μM.hr) 253.33±100.32 252.6=0,4 %, n.s.)
*

In vivo human clinical data Rajkumar et al. 39

**

AUC was computed for times when clinical measurements were available for both in vivo and in silico studies