Table 3.

Predictions of human PK parameters for oral nicotine (a) and intravenous cisplatin (b) obtained with the multi-Organ Chip IVIVT platform compared to clinical values and rodent clearance results.

a
	Organ PK Parameters – Nicotine
		PK Parameter	Rodent (in vivo)	Human (Clinical data)	In Silico Model (Multi-Organ Chips)
	Gut	Papp (10−6 m/s)	NA	9.5 to 57.2	1.3 to 7.5 (δ=21-98%) ****
	Liver	Intrinsic Clearance, CLint (ml/min/kg.BW)	300	12.5	10.0 (δ=20 %) 8.004 (δ=36,0 %)
		Secondary Intrinsic Clearance, CLint, sec (ml/min/kq.BW)	NA	0.74	0.15 (δ=80,0 %)
	Kidney	Renal Clearance, CLR, (ml/min/kg.BW)	5.5	0.5 to 1.29	0.03 to 0.13 (δ=75-98%) ****
b
	Organ PK Parameters - Cisplatin
		PK Parameter	Rodent (in vivo)	Human (Clinical data)	In Silico Model (Multi-Organ Chips)
	Liver	Intrinsic Clearance, CLint (ml/min/kg.BW)	3.73	0.25	0.20 (δ=20,0 %)
	Kidney	Renal Clearance, CLR (ml/min/kg.BW)	0.19	1.39	0.008 (δ=99,4 %)

Comments for Table 3a.

^*In vivo data from Digard et al. ²⁸ (human) and Yamazaki et al ³⁵ (rodent)

^**AUC was computed for t=0 to 2hrs (i.e., times when clinical measurements were available) for both in vivo and in silico studies

Comments for Table 3b

^*In vivo data from Rajkumar et al. ³⁹ (human) and Gong et al.⁶⁹ (rodent) – where total cisplatin clearance was used for liver clearance and clearance out of tissue for kidney

^****Minimum to maximum % relative error in the interval