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. Author manuscript; available in PMC: 2021 Mar 31.
Published in final edited form as: Nat Cancer. 2020 Oct 19;1(11):1113–1127. doi: 10.1038/s43018-020-00124-1

Extended Fig. 4 |. Schematics of the protein structures showing mutations recurrently identified in diagnostic and relapse ALL samples.

Extended Fig. 4 |

Extended Fig. 4 |

Proteins involved in chemotherapy resistance and signaling are represented. Black circles indicate amino acid substitutions. Red circles indicate truncating mutations. TAD, transactivation domain; HAD haloacid dehalogenase domain; SB, substrate binding; Zn, zinc finger domain; LBD, ligand binding domain; P, P loop domain; SWI, Switch I domain; SWII, Switch II domain; HVR, hypervariable region domain; FERM, 4.1 protein Ezrin Radixin Moesin domain; SH2 like, Src homology 2 like domain; FZ, Frizzled domain; GPCR, GPCR family 2-like; Ig, Immunoglobulin; PTPase, Tyrosine specific protein phosphatases domain; HEAT, Huntingtin, EF3A, ATM, TOR; FAT, Frap, ATM, TRRAP; FRB, FKBP-rapamycin complex binding; RD, regulatory domain; FATC, FAT C-terminal; B41, Band 4.1 homologues; PH-like, Pleckstrin homology-like; EGF like, epidermal growth factor like domain repeats; LNR, Lin12-Notch repeats; HD, heterodimerization domain; TM, transmembrane region; RAM, Rbp-associated molecule domain; ANK, ankyrin repeats; PEST, proline (P), glutamic acid (E), serine (S), and threonine (T) domain; FN3, Fibronectin type III; OD, oligomerization domain; SH3, Src homology 3 domain; FABD, F-actin binding domain.