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. Author manuscript; available in PMC: 2021 Mar 31.
Published in final edited form as: Nat Cancer. 2020 Oct 19;1(11):1113–1127. doi: 10.1038/s43018-020-00124-1

Figure 3 |. Genome wide CRISPR analysis of chemotherapy-gene interactions.

Figure 3 |

a, Schematic illustration of inducible Genome-Scale CRISPR/Cas9 knock-out screening in REH B-precursor ALL cells. b-h, CRISPR screen results and schematic representation for drug-gene interactions across seven chemotherapy drugs. Genes are ranked based on the enrichment of their respective gRNAs compared to vehicle-treated controls. Red and blue circles in b-h indicate genes with enriched and depleted gRNAs (FDR < 0.05), respectively.