Table 4.

Latent profile analysis marginal means and 95% confidence intervals of symptoms reported by phase of childhood ALL therapy

	N (%)	Fatigue	Sleep	Pain	Nausea
End Induction
Class 1	95 (49.5)	46.02 (44.13–47.91)	2.56 (2.40–2.72)	1.84 (1.56–2.11)	0.20 (0.09–0.31)
Class 2	62 (32.3)	48.88 (46.56–51.21)	2.65 (2.46–2.84)	2.47 (2.06–2.87)	14.38 (13.15–15.62)
Class 3	35 (18.2)	54.36 (51.19–57.52)	3.14 (2.88–3.40)	4.05 (3.36–4.75)	55.14 (52.01–58.27)
Delayed Intensification Day 1
Class 1	90 (46.2)	46.25 (44.40–48.09)	2.50 (2.34–2.66)	0.71 (0.53–0.88)	0.09 (0.01–0.17)
Class 2	58 (29.7)	48.16 (45.8O-5O.52)	2.95 (2.75–3.16)	1.65 (1.31–1.98)	9.19 (8.28–10.10)
Class 3	47 (24.1)	56.66 (53.98–59.34)	3.01 (2.73–3.29)	2.50 (2.03–2.97)	43.83 (41.74–45.92)
Maintenance Cycle 1 Day 1
Class 1	78 (45.1)	45.20 (43.24–47.15)	2.50 (2.33–2.68)	0.72 (0.52–0.91)	0.13 (0.04–0.23)
Class 2	66 (38.2)	51.92 (49.65–54.19)	2.87 (2.68–3.07)	1.46 (1.14–1.77)	12.83 (11.70–13.97)
Class 3	29 (16.8)	57.06 (53.62–60.50)	3.02 (2.69–3.35)	1.97 (1.42–2.52)	50.85 (47.19–54.51)
Maintenance Cycle 2 Day 1
Class 1	88 (53.0)	47.08 (45.13–49.04)	2.56 (2.37–2.74)	0.64 (0.47–0.81)	0.25 (0.12–0.39)
Class 2	51 (30.7)	53.62 (51.01–56.24)	2.85 (2.62–3.08)	1.42 (1.05–1.78)	11.84 (10.59–13.09)
Class 3	27 (16.3)	56.30 (52.80–59.80)	2.81 (2.44–3.18)	2.44 (1.82–3.06)	43.87 (40.83–46.92)