Table 5.

Observed association between latent profile classes at four time points during therapy and relapse among cases of childhood ALL

	Relapse Cases	Total Cases	Adjusted HR (95% CI)1	P for Trend
End Induction
Class 1	6	95	Ref.	0.07
Class 2	7	62	1.66 (0.60–4.56)
Class 3	7	35	3.31 (0.95–11.58)
Delayed Intensification Day 1
Class 1	6	90	Ref.	0.01
Class 2	8	58	2.26 (0.76–6.69)
Class 3	6	47	3.98 (1.38–11.46)
Maintenance Cycle 1 Day 1
Class 1	7	78	Ref.	0.32
Class 2	7	66	1.41 (0.47–4.23)
Class 3	2	29	2.39 (0.39–14.53)
Maintenance Cycle 2 Day 1
Class 1	6	88	Ref.	0.11
Class 2	6	51	2.68 (0.82–8.79)
Class 3	3	27	2.29 (0.59–8.92)

¹Model adjusted for age, gender, ethnicity, BMI z-score at diagnosis, diagnosis, and treatment risk group