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. Author manuscript; available in PMC: 2021 Mar 31.
Published in final edited form as: Bioorg Med Chem Lett. 2019 Dec 17;30(4):126899. doi: 10.1016/j.bmcl.2019.126899

Table 3.

SAR of benzothiazole analogs.

graphic file with name nihms-1680297-t0004.jpg
Entry R CXCR6: β-arrestin CXCR6: cAMP
IC50 (μM) % response IC50 (μM) % response
73 4-Cl 0.13 103 0.9 95
74 5-Cl 0.17 100 3.2 90
75 6-Cl 0.27 103 14.0 83
76 7-Cl 0.26 102 8.9 93
77 4-F 0.11 103 1.9 105
78 4-Me 0.25 100 4.8 86
79 4-OMe 3.1 86 > 50 NA
80 4-Br 0.08 102 1.0 91
81 4-CF3 0.04 103 0.5 98