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. 2021 Mar 31;138:111544. doi: 10.1016/j.biopha.2021.111544

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 4 — Trovafloxacin (Trovan) had a binding affinity of − 8.9 kcal/mol. The picture shows the interactions between Trovafloxacin (Trovan) and the viral 3CLpro. a. The picture represents the results for the analysis of interactions between Trovan and 3CLpro. H bonds, conventional and Pi-donor H-bonds, and hydrophobic interactions are depicted using various colors described in the picture guide of interaction colors below the shape. b. The picture shows the 3D docking interactions between Trovan and 3CLpro residues. H bonds are shown with green dashed lines. c. Position of Trovan in the pocket 3CLpro active site. d. The 3D picture shows the interactions between Trovan and 3CLpro active site’ critical residues. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)